The Latest Method for Surface Tension Determination: Experimental Validation

The Surface Tension of Blood Serum, and the Determination of the Surface Tension of Biological Fluids.

This investigation was undertaken in order to obtain a more exact knowledge of the surface tension of undiluted blood serum, and its variation under various clinical conditions, than is given by the work reported earlier by others (1-12). It was found that practically all previous investigators have made errors in the experimental procedure or in the calculation of their results, usually in bot...

Non Aqueous Titration for the Determination of Azelaic Acid: Introduction and Method Validation

Alpha-hydroxylic acids are widely used in the treatment and control of skin disorders. Azelaic acid is a naturally occuring Alpha-hydroxy acid that can be formed endogenously from long-chain dicardoxylic acids, metabolism of oleic acid or omega oxidation of mono carboxylic acids. It shows bacteriostatic and bactericidal activities against aerobic and anaerobic micro-organisms present on acne-be...

The Determination of the Bile Salts in Urine by Means of the Surface Tension Method

Development and Validation of RP-HPLC-UV Method for Determination of Diclofenac Sodium Residues on Surfaces for Cleaning Validation

In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

Multiple histogram reweighting method for the surface tension calculation.

The multiple histogram reweighting method takes advantage of calculating ensemble averages over a range of thermodynamic conditions without performing a molecular simulation at each thermodynamic point. We show that this method can easily be extended to the calculation of the surface tension. We develop a new methodology called multiple histogram reweighting with slab decomposition based on the...